臨床研究支援事業
CSP-A-TOP《骨粗鬆症至適療法研究支援事業》
Comprehensive Support Project for Adequate Treatment of Osteoporosis
成果一覧
J-05
J Bone Miner Metab; 2023 Oct 28. doi: 10.1007/s00774-023-01466-3
Reliability of early stage symptoms/clinical findings of osteonecrosis of the jaw: Japanese Osteoporosis Intervention Trial-05 (JOINT-05), Akira Taguchi, Shiro Tanaka, Tatsuro Ozaki, Koshiro Arai, Satoshi Mori, Hiroaki Ohta, Hiroshi Hagino, Sakae Tanaka, Masataka Shiraki, Toshitaka Nakamura, Satoshi Soen; Adequate Treatment of Osteoporosis (A-TOP) Research Group
Osteoporosis International; https://doi.org/10.1007/s00198-022-06570-0
Sequential therapy with once‑weekly teriparatide injection followed by alendronate versus monotherapy with alendronate alone in patients at high risk of osteoporotic fracture: final results of the Japanese Osteoporosis Intervention Trial‑05. Mori, S., Hagino, H., Sugimoto, T., Tanaka, S., Mitomo, Y., Takahashi, K.
Osteoporosis International; https://doi.org/10.1007/s00198-021-05996-2
A randomized, controlled trial of once-weekly teriparatide injection versus alendronate in patients at high risk of osteoporotic fracture: primary results of the Japanese Osteoporosis Intervention Trial-05. Hagino, H., Sugimoto, T., Tanaka, S., Sone, T., Nakamura, T., Soen, S., Mori, S.
J Bone Miner Metab ; 2020, 38, 412–417.
Design of a randomized trial of teriparatide followed by alendronate:Japanese Osteoporosis Intervention Trial‑05 (JOINT‑05). Tanaka, S., Mori, S., Hagino, H., Sugimoto, T.
J-04
Arch Osteoporos. 2021 Dec 27;17(1):7. doi: 10.1007/s11657-021-01054-w.
Influence of symptomatic periodontal disease on changes in skeletal bone density during medication therapy for osteoporosis in postmenopausal women: the Japanese Osteoporosis Intervention Trial (JOINT)-04 and JOINT-05. Taguchi, A., Uemura, Y., Tanaka, S., Ohta, H., Mori, S., Hagino, H., Shiraki, M., Nakamura, T., Soen, S., for the Adequate Treatment of Osteoporosis (A-TOP) research. group.
J Bone Miner Metab; 2021, 39:668-677. doi: 10.1007/s00774-021-01208-3.
Risk factors for incident vertebral fractures in osteoporosis pharmacotherapy: a 2-year, prospective, observational study. Hagino, H., Uemura, Y., Mori, S., Sone, T., Ohta, H., Nakamura, T.
Curr Med Res Opin; 2020,36(11),1847-1859. doi: 10.1080/03007995.2020.1816537. Epub 2020 Sep 14
Randomized head-to-head comparison of minodronic acid and raloxifene for fracture incidence in postmenopausal Japanese women: the Japanese Osteoporosis Intervention Trial (JOINT)-04. Uemura, Y., Sone, T., Tanaka, S., Miyazaki, T., Tsukiyama, M., Taguchi, A., Soen, S., Mori, S., Hagino, H., Sugimoto, T., Fukunaga, M., Ohta, H., Nakamura, T., Orimo, H., Shiraki, M., for the Adequate Treatment of Osteoporosis (A-TOP) Research Group.
J Bone Miner Metab ; 2019,37, 886–892.
Incidence of osteonecrosis of the jaw in Japanese osteoporosis patients taking minodronic acid. Taguchi, A., Uemura, Y., Imai, T., Tanaka, S., Ohta, H., Nakamura, T., Orimo, H., Sugimoto, T., Soen, S., Shiraki, M., for the Adequate Treatment of Osteoporosis(A-TOP) research group.
J Bone Miner Metab; 2019,37(3),491-495. doi: 10.1007/s00774-018-0942-z. Epub 2018 Jul 17.
Study design of multi-center, open-label randomized controlled, head-to-headtrial comparing minodronic acid and raloxifene: Japanese Osteoporosis Intervention Trial (JOINT)-04. Uemura, Y., Tanaka, S., Miyazaki, T., Tsukiyama, M., Sone, T., Taguchi, A., Soen, S., Mori, S., Hagino, H., Sugimoto, T., Fukunaga, M., Ohta, H., Nakamura, T., Orimo, H., Shiraki, M., for the Adequate Treatment of Osteoporosis (A-TOP) research group.
J-03
Osteoporos Int; 2017,28(6),1893-1901.DOI 10,1007/S 00198-017-3966-7
Health state utility values and patient-reported outcomes before and after vertebral and non-vertebral fractures in an osteoporosis clinical trial. Imai, T., Tanaka, S., Kawakami, K., Miyazaki, T., Hagino, H., Shiraki, M., for the A-TOP(Adequate Treatment of Osteoporosis) Research Group.
J Bone Miner Metab ; 2017,35(4);385-395.DOI 10.1007/s00774-016-0768-5
Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03. Tanaka, S., Miyazaki, T., Uemura, Y., Miyakawa, N., Gorai, I., Nakamura, T., Fukunaga, M., Ohashi, Y., Ohta, H., Mori, S., Hagino, H., Hosoi, T., Sugimoto, T., Itoi, E., Orimo, H., Shiraki, M.
J Bone Miner Metab;32(3); 298-304, 2014
Design of a randomized clinical trial of concurrent treatment with vitamin K2 and risedronate compared to risedronate alone in osteoporotic patients: Japanese Osteoporosis Intervention Trial-03 (JOINT-03). Tanaka, S., Miyazaki, T., Uemura, Y., Kuroda, T., Miyakawa, N., Nakamura, T., Fukunaga, M., Ohashi, Y., Ohta, H., Mori, S., Hagino, H., Hosoi, T., Sugimoto, T., Itoi, E., Orimo, H., Shiraki, M.
J-02
J Orthop Sci. ; 2020,S0949-2658(20)30332-8.
Impact of bone mineral density in reducing fracture risk in patients receiving alendronate plus alfacalcidol therapy. Itoi, E., Uemura, Y., Ohta, H., Nakamura, T., Fukunaga, M., Orimo, H., Shiraki, M.
Clin Therap; 2014,36(2),225-235.
Serum 25 hydroxyvitamin D level as an independent determinant of quality of life in osteoporosis with high risk for fracture. Ohta, H., Uemura, Y., Nakamura, T., Fukunaga, M., Ohashi, Z., Hosoi, T., Mori, S., Sugimoto, T., Itoi, E., Orimo, H., Shiraki, M., Adequate Treatment of Osteoporosis.(A-TOP)research group.
J Bone Miner Metab; 2015,33(6):,642-650.
Comparison of expert and nonexpert physicians in the assessment of vertebral fractures using the semiquantitative method in Japan. Uemura, Y., Miyakawa, N., Orimo, H., Shiraki, M., Nakamura, T., Mori, S.
Curr Med Res Opin; 2011,27(6),1273-84.
Effects of alendronate plus alfacalcidol in osteoporosis patients with a high risk of fracture: the Japanese Osteoporosis Intervention Trial (JOINT)- 02. Orimo, H., Nakamura, T., Fukunaga, M., Ohta, H., Hosoi, T., Uemura, Y., Kuroda, T., Miyakawa, N., Ohashi, Y., Shiraki, M., A-TOP (Adequate Treatment of Osteoporosis)research group.
J Bone Miner Metab; 2011,29(1),37-43.
Design of a pragmatic approach to evaluate the effectiveness of concurrent treatment for the prevention of osteoporotic fractures: rationale, aims and organization of a Japanese Osteoporosis Intervention Trial(JOINT) initiated by the Research Group of Adequate Treatment of Osteoporosis (A-TOP). Shiraki, M., Kuroda, T., Hosoi, T., Ohashi, Y., Ohta, H., Fukunaga, M., Nakamura, T., Orimo, H.,et al.
A-01
Journal of Epidemiology;https://doi.org/10.2188/jea.JE20220099
Impact of Osteonecrosis of the Jaw on Osteoporosis Treatment in Japan: Results of a Questionnaire-Based Survey by the Adequate Treatment of Osteoporosis (A-TOP) Research Group. Imai, T., Hosoi, T., Hagino, H., Yamamoto, T., Kuroda, T., Watanabe, H., Tanaka, S.
Jpn J Pharmacoepidemiol;21(1);13-19,2016,DOI.org/10.3820/jjpe.21.13
Validation Study of Claims-based Definitions of Suspected Atypical Femoral Fractures Using Clinical Information. Tanaka, S., Hagino, H., Ishizuka, A., Miyazaki, T., Yamamoto, T., Hosoi, T.